Encore: Why Normal Cholesterol Doesn't Always Mean Low Heart Disease Risk

Jun 29, 2026 · 29 min

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EP · The Dr. Hyman Show · Encore: Why Normal Cholesterol Doesn't Always Mean Low Heart Disease Risk29:26

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Transcript

asr · 5,790 words · docs

0:00Let me ask you this.

0:01If cholesterol were truly the main cause of heart disease, then why do half the people who have heart attacks have normal LDL levels?

0:07And there was a study of like 136,000 people who had heart attacks went to ER, and 75% had a, quote, normal LDL level.

0:14So that begs the question, then what the hell is going on here?

0:17Welcome back to Office Hours.

0:18Over the summer, we're revisiting a few of the conversations that resonated with most with our audience.

0:22And this one was at the very top of the list.

0:25When this episode first aired, it sparked a huge response because it challenged something many of us have been told for decades, and that is this.

0:32Cholesterol is the primary driver of heart disease.

0:35Well, it might not be, and you'll find out why if you listen.

0:38In this conversation, I dive into the latest science around cholesterol and inflammation, around insulin resistance and something they call APOB, which is super important to know about, and metabolic health.

0:47And I ask whether we've been focusing on the wrong markers all along.

0:50What's interesting is that since this episode first came out, the conversation around cardiovascular risk has only continued to evolve.

0:56And listening back today, many of these insights feel even more relevant than they did the first time.

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